Bristol Myers Squibb delivered a stronger-than-anticipated second-quarter performance, showcasing resilience fueled by its established blockbuster medications and effective commercial strategies. Despite widespread analyst expectations of a revenue decline, primarily due to the expiration of patent protections on key products, the pharmaceutical giant surpassed forecasts, demonstrating its ability to navigate a challenging market landscape.
- Bristol Myers Squibb’s Q2 revenue reached $12.3 billion, a 1% increase, significantly exceeding analyst estimates.
- Earnings per share for Q2 stood at $1.46, well above forecasts.
- Sales of the blood thinner Eliquis rose 8% to $3.7 billion, and cancer immunotherapy Opdivo increased 7% to $2.6 billion.
- Revlimid sales declined 38% to $838 million due to generic competition but surpassed analyst expectations by approximately $300 million.
- The company raised its 2025 sales outlook for Revlimid to approximately $3 billion.
- Full-year revenue guidance was revised upwards to between $46.5 billion and $47.5 billion, with full-year EPS expected between $6.35 and $6.65.
Robust Financial Performance in Q2
The company’s second-quarter revenue reached $12.3 billion, marking a 1% increase and significantly exceeding the average analyst estimate of $11.4 billion, according to data compiled by LSEG. Concurrently, earnings per share stood at $1.46, well above the anticipated $1.07, though lower than the $2.07 reported in the prior year. This financial outperformance was largely attributed to the robust sales of its leading brands, underscoring the effectiveness of the company’s market approach.
Key Product Drivers
Driving this positive outcome were the strong sales figures for the blood thinner Eliquis and the cancer immunotherapy Opdivo. Eliquis, which Bristol Myers Squibb co-markets with Pfizer, saw an 8% increase in sales to $3.7 billion, while Opdivo generated $2.6 billion, up 7% from a year ago. Both figures comfortably surpassed analyst projections, illustrating the sustained demand for these critical medications. “The majority of our brands outperformed consensus in the quarter,” stated Chief Financial Officer David Elkins, highlighting the profound impact of “really solid commercial execution” on these results.
Navigating Patent Expirations: The Revlimid Case
A significant factor in the quarter’s narrative was the performance of Revlimid, a key multiple myeloma drug. While sales of the drug experienced a substantial 38% decline to $838 million due to increasing generic competition, this figure still exceeded analyst expectations by approximately $300 million. This resilience is particularly notable given Revlimid’s revenue trajectory, which has plummeted from nearly $13 billion in 2021 to $5.8 billion last year as it faces the expiration of its core patents. Other cancer treatments like Pomalyst, Sprycel, and Abraxane are also contending with similar patent expiration challenges. However, Revlimid’s stronger-than-feared hold on market share prompted Chief Commercialization Officer Adam Lenkowsky to raise the company’s 2025 sales outlook for the drug to around $3 billion, an increase from a previous projection near $2.5 billion. This revised outlook reflects confidence in the drug’s enduring market presence despite mounting generic pressure.
Optimistic Full-Year Outlook
Looking ahead, Bristol Myers Squibb has revised its full-year financial guidance upwards, signaling optimism for its strategic trajectory. The company now anticipates full-year revenue to range between $46.5 billion and $47.5 billion, an increase from its prior outlook of $45.8 billion to $46.8 billion. Furthermore, full-year earnings, including a charge from a development deal with BioNTech, are now expected to be between $6.35 and $6.65 per share, a favorable comparison to analyst estimates of approximately $6.24 per share for 2025. This updated outlook underscores the company’s confidence in its strategic approach and the sustained performance of its core product portfolio amidst evolving market dynamics and patent challenges.

Lucas turns raw market data into actionable strategies, spotting trends in a heartbeat. With 9 years managing portfolios, he treats market volatility like a surfer riding big waves—balance and timing are everything. On weekends, Lucas hosts “Bull & Bear Banter” podcasts, showing that finance discussions can be as entertaining as they are informative.